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    changelog tag

    what changed in tools, week by week.

    11 weeks that touched tools, newest first. where a week has a tools section, only that section is shown.

    the whole changelog

    FY26 Q4 · Oct 5 – Oct 19

    covers Oct 12–19, 2026

    fork a chat you don't own, and retry a failed job

    provenance: agent (anthropic/claude-sonnet-5.5) from commit history; reviewed in PR before publishing.

    tools#

    • DiffDock docks against the receptor chains you name. For peptide and biologic ligands it points you to Boltz-2 or Chai-1 before any compute runs.
    • Boltz-2 returns the structure when a ligand is too large for an affinity estimate, rather than failing the whole run.
    • MM/GBSA scores a complex already in your workspace, as well as pasted structure text.
    • The tool catalogue lists BoltzGen and Chai-1 by name, with the plan each one needs.

    FY26 Q3 · Jul 20 – Sep 28

    covers Sep 21–28, 2026

    failed job cards say why, and api answers arrive once

    provenance: agent (anthropic/claude-sonnet-5.5) from commit history; reviewed in PR before publishing.

    tools#

    • Octave, Opentrons protocol generation and PyLabRobot run in the chat sandbox, alongside your other code and files.
    • ProteinMPNN keeps the structure you named through to the run.
    • ClinPGx filters match on the variant fields in the data, and RxNorm lookups return the identifiers and ingredient concepts.
    covers Aug 24–31, 2026

    igblast cards show the full v, d and j picture

    provenance: agent (anthropic/claude-sonnet-5.5) from commit history; reviewed in PR before publishing.

    tools#

    • ThermoMPNN accepts mutations written as S31A, or with a chain prefix as H:S31A.
    • ddG and mutation-scan requests go to binding ddG and ThermoMPNN rather than a general tool.
    • Antibody, peptide and vaccine lookups go to sources that hold biologics, instead of a small-molecule database that can't answer them.
    covers Jul 27 – Aug 3, 2026

    reloaded chats keep the whole conversation

    provenance: agent (anthropic/claude-sonnet-5.5) from commit history; reviewed in PR before publishing.

    tools#

    • Free energy perturbation runs when you ask for it by name, on 2 to 20 compounds.
    • Pocket prediction runs on a PDB or UniProt id. Structure, docking and design tools accept a PDB you just downloaded in the same chat, so a pipeline can go straight from download to design.
    • 4DN file and experiment-set accessions pasted into a message go to the right lookup.
    covers Jul 20–27, 2026

    batch results land in the chat, and a declined run stays declined

    provenance: agent (anthropic/claude-sonnet-5.5) from commit history; reviewed in PR before publishing.

    tools#

    • Clinical entity extraction, clinical summarisation, ICD coding, and flow cytometry gating and differential analysis are available in chat. Ask for them by name or describe the task.
    • A 4DN experiment search that returns nothing says so plainly, instead of continuing to a Hi-C step with no input files.
    catch-upcovers Jan 1 – Jul 20, 2026

    january to july 2026: a canvas, a sandbox in every chat, and the cli

    provenance: agent (anthropic/claude-sonnet-5.5) from commit history; reviewed in PR before publishing.

    tools#

    • The tool catalogue grew across single-cell and spatial analysis, genomics and pharmacogenomics, clinical and regulatory data, proteomics, crystallography and lab automation. Examples include clinical trial search, adverse-event signal scans, gnomAD variants, pharmacogene star alleles, GEO and PRIDE datasets, ENCODE, L1000 signatures, P2Rank pockets and ZINC22 compounds.
    • Reports and documents compile to PDF from a chat, with templates for common write-ups.
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