---
title: "Generative & De Novo overview"
description: "Propose novel small molecules toward a target profile with REINVENT or GenMol, then plan a retrosynthesis route for what you decide to make."
tags:
  - section
  - generative
generated: true
---

When existing compounds don't fit, generate new ones. This section proposes novel molecules — or grows and decorates a fragment — toward a target profile, expanding chemical space beyond what's already been made. It pairs naturally with docking and ADMET to score what you generate.

> **Availability**

> These tools are metered by credits and gated by your plan — plans set your monthly credits, available model families, and which modal-app tools you can run. See [Plans & tiers](/docs/plans-and-tiers).

## What you can achieve here

- Generate novel small molecules toward a target
- Grow or decorate a fragment
- Design toward a desired property profile

For which tool fits each, see [What you can achieve](/docs/capabilities).

## Tools in this section

| Tool | What it does |
|---|---|
| [REINVENT](/docs/reinvent) | Design molecules with REINVENT 4 reinforcement learning, scoring functions and diversity filters — soft-deprecated here in favour of GenMol. |
| [GenMol](/docs/genmol) | Generate novel molecules using masked discrete diffusion on SAFE representations. |
| [AiZynthFinder](/docs/aizynthfinder) | Break a target SMILES into purchasable starting materials with AiZynthFinder — Monte Carlo tree search over USPTO templates, scored against your… |

## Recipes using these tools

## Read next