---
title: "Targets & Modalities overview"
description: "Guide RNA design and off-target analysis, PROTAC linker and ternary complex modeling, tumor mutational burden, and genome-scale flux balance analysis."
tags:
  - section
  - targets-modalities
generated: true
---

Specialized target classes and drug modalities that need their own tooling — CRISPR, PROTACs, oncology analytics, and systems biology. Reach here when your program's modality doesn't fit the standard small-molecule arc.

> **Availability**

> These tools are metered by credits and gated by your plan — plans set your monthly credits, available model families, and which modal-app tools you can run. See [Plans & tiers](/docs/plans-and-tiers).

## What you can achieve here

- Design CRISPR experiments
- Work with PROTACs and targeted degradation
- Run oncology-specific analyses
- Model systems-biology networks

For which tool fits each, see [What you can achieve](/docs/capabilities).

## Tools in this section

| Tool | What it does |
|---|---|
| [CRISPR on the platform](/docs/crispr) | Guide RNA design, off-target analysis, and CRISPR screen hit identification for genome editing experiments. |
| [PROTAC design on the platform](/docs/protac) | Targeted protein degradation tools for PROTAC linker enumeration, ternary complex modeling, and degradation efficiency prediction. |
| [Oncology Analytics on the platform](/docs/oncology) | Computational oncology tools for tumor mutational burden, microsatellite instability, and immunotherapy biomarker prediction. |
| [Systems Biology on the platform](/docs/systems-biology) | Flux balance analysis, metabolic model construction, and gene essentiality prediction tools for genome-scale metabolic modeling. |

## Read next