ANARCI inputs and parameters
Submit up to 100 variable-region sequences and pick the scheme that sets CDR boundaries — imgt, chothia, kabat, aho or wolfguy — or name a known antibody.
You provide one or more antibody variable-region sequences — heavy, light, or both — and choose a numbering scheme. The scheme is the parameter that most affects how you read the result: it decides where CDR and framework boundaries fall and which position labels every downstream tool will use. Everything else has a sensible default.
Sequences
ANARCI accepts a list of antibody variable-region amino acid sequences (heavy or light). Submit between one and 100 sequences per job; name them if you want the labels carried through to the result card.
sequencesstring[]requiredAntibody variable-region amino acid sequences. One to 100 per job.
sequence_namesstring[]Optional names for each sequence, carried through to the result.
Numbering scheme
The scheme determines the canonical position labels and where CDR and framework boundaries fall. IMGT is the default and the most common choice; pick another only when a downstream tool or lab convention requires it.
schemestringdefault: imgtNumbering scheme: imgt, chothia, kabat, aho, or wolfguy.
Germline and compute
assign_germlinebooldefault: trueAssign the closest germline V and J genes to each chain.
ncpuintdefault: 4CPUs to use for the HMMER alignment step (1–8).
From a therapeutic name
The anarci_number tool also accepts a therapeutic_name — name a known antibody (for example nivolumab) and the platform resolves its VH/VL from Thera-SAbDab before numbering, so you don't have to paste sequences.
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