Ask Ivy in chat for measured activity against a target — name a ChEMBL ID like CHEMBL203, an activity type like IC50 and a nM cutoff, then read the pChEMBL rows.

You want to find compounds with measured activity against a target and see their potencies; this searches ChEMBL bioactivity data and returns a filtered hit table in a single query.

ChEMBL Quickstart

Search ChEMBL for EGFR inhibitors with known bioactivity data.

Via Chat

Type a natural-language query:

Search ChEMBL for EGFR inhibitors with IC50 < 100 nM

The AI selects the bioactivity search mode, uses CHEMBL203 (EGFR's ChEMBL ID), and applies the potency filter automatically.

ChEMBL searches run when you ask Ivy in chat; there is no separate form or job for them. If you already know the target's ChEMBL ID, the activity type, or the cutoff you want, put them in the question:

Search ChEMBL bioactivity for target CHEMBL203, IC50 only, below 100 nM

Interpret Results

Results appear as a data table on the canvas showing:

Compound SMILES and ChEMBL IDs
Activity values (IC50 in nM) and pChEMBL value
Assay type and assay description
Target name and organism

Next Steps

Screen for drug-likeness: Select hits and run ADMETLab3 or ADMET-AI
Dock top compounds: Send SMILES to DiffDock with an EGFR structure (PDB 1M17)
Generate a compound passport: Create a full profile for your best hit
Find analogs: Use a hit's SMILES for a similarity search to expand the hit series

ChEMBL quickstart