UniProt quickstart
Search for a protein in UniProt and chain the sequence into structure prediction.
You want a protein's sequence and annotations to start a structure pipeline; this searches UniProt, then chains the sequence straight into ESMFold structure prediction.
UniProt Quickstart
Search
In chat, ask for a protein:
The platform queries the UniProt API and returns matching protein entries.
Review Annotations
Results include:
- Protein name and gene symbol
- Accession ID (e.g., P00533)
- Organism and taxonomy
- Function description
- GO terms — molecular function, biological process, cellular component
- Sequence — full amino acid sequence
- Cross-references — PDB entries, Pfam domains, InterPro families
Chain into Structure Prediction
Ask the platform to predict the structure:
Or chain directly in one prompt:
Continue the Pipeline
After folding, you can:
- Predict binding sites: Run P2Rank on the predicted structure
- Run a similarity search: Send the sequence to BLAST
- Build a target passport: Generate a comprehensive target profile
Next Steps
- Ask for the whole chain in one message ("Fold P00533 and find its binding pockets") and the orchestrator runs UniProt → ESMFold → P2Rank for you
- Search for homologs with BLAST
- Generate embeddings with ESM-3
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UniProt Search outputs
Read entry_type, function, GO terms and feature positions off each entry, then follow cross_references to PDB, ChEMBL and AlphaFold or fold the sequence.
UniProt Search troubleshooting
No results or the wrong protein? Name the right organism or drop it, check for a retired accession, and ask for the sequence when it is missing.