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latest article · Protein Engineering

ThermoMPNN vs ESM Zero-Shot vs FoldX for Stability ΔΔG

ThermoMPNN, FoldX and an ESM zero-shot scan answer three different questions about a point mutation, and only two of them are in kcal/mol. A benchmark-anchored comparison of what each method predicts, where each one fails, and what the wet-lab comparator actually measures.